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Research Article

Rapid Insulinotropic Action of Low Doses of Bisphenol-A on Mouse and Human Islets of Langerhans: Role of Estrogen Receptor β

  • Sergi Soriano,

    Affiliation: Instituto Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández de Elche, Elche, Alicante, Spain

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  • Paloma Alonso-Magdalena,

    Affiliation: Instituto Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández de Elche, Elche, Alicante, Spain

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  • Marta García-Arévalo,

    Affiliation: Instituto Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández de Elche, Elche, Alicante, Spain

    X
  • Anna Novials,

    Affiliation: Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and CIBERDEM, Barcelona, Spain

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  • Sarheed J. Muhammed,

    Affiliation: Department of Clinical Sciences, Lund University, Malmö, Sweden

    X
  • Albert Salehi,

    Affiliation: Department of Clinical Sciences, Lund University, Malmö, Sweden

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  • Jan-Ake Gustafsson,

    Affiliation: Department of Cell Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, United States of America

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  • Ivan Quesada,

    Affiliation: Instituto Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández de Elche, Elche, Alicante, Spain

    X
  • Angel Nadal mail

    nadal@umh.es

    Affiliation: Instituto Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández de Elche, Elche, Alicante, Spain

    X
  • Published: February 08, 2012
  • DOI: 10.1371/journal.pone.0031109

About the Authors

Sergi Soriano, Paloma Alonso-Magdalena, Marta García-Arévalo, Ivan Quesada, Angel Nadal
Instituto Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández de Elche, Elche, Alicante, Spain
Anna Novials
Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and CIBERDEM, Barcelona, Spain
Sarheed J. Muhammed, Albert Salehi
Department of Clinical Sciences, Lund University, Malmö, Sweden
Jan-Ake Gustafsson
Department of Cell Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, United States of America

Corresponding Author

Email: nadal@umh.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS PA-M IQ A. Nadal. Performed the experiments: SS PA-M MG-A SM. Analyzed the data: SS PA-M MG-A SM AS A. Nadal. Contributed reagents/materials/analysis tools: A. Novials AS JAG IQ A. Nadal. Wrote the paper: A. Nadal.