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Research Article

High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting

  • Michelle Cronin,

    Affiliation: Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jr. Laboratory, University College Cork, Cork, Ireland

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  • Ali R. Akin,

    Affiliation: Caliper – a PerkinElmer Company, Alameda, California, United States of America

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  • Sara A. Collins,

    Affiliations: Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jr. Laboratory, University College Cork, Cork, Ireland, School of Medicine, University of California Los Angeles, Los Angeles, California, United State of America

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  • Jeff Meganck,

    Affiliation: Caliper – a PerkinElmer Company, Alameda, California, United States of America

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  • Jae-Beom Kim,

    Affiliation: Caliper – a PerkinElmer Company, Alameda, California, United States of America

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  • Chwanrow K. Baban,

    Affiliation: Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jr. Laboratory, University College Cork, Cork, Ireland

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  • Susan A. Joyce,

    Affiliation: Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

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  • Gooitzen M. van Dam,

    Affiliation: Department of Surgery, Division of Surgical Oncology, BioOptical Imaging Center, University of Groningen, Groningen, The Netherlands

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  • Ning Zhang,

    Affiliation: Caliper – a PerkinElmer Company, Alameda, California, United States of America

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  • Douwe van Sinderen,

    Affiliation: Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

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  • Gerald C. O'Sullivan,

    Affiliation: Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jr. Laboratory, University College Cork, Cork, Ireland

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  • Noriyuki Kasahara,

    Affiliation: School of Medicine, University of California Los Angeles, Los Angeles, California, United State of America

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  • Cormac G. Gahan,

    Affiliations: Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland, School of Pharmacy, University College Cork, Cork, Ireland

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  • Kevin P. Francis,

    Affiliation: Caliper – a PerkinElmer Company, Alameda, California, United States of America

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  • Mark Tangney mail

    m.tangney@ucc.ie

    Affiliations: Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jr. Laboratory, University College Cork, Cork, Ireland, School of Medicine, University of California Los Angeles, Los Angeles, California, United State of America

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  • Published: January 25, 2012
  • DOI: 10.1371/journal.pone.0030940

About the Authors

Michelle Cronin, Sara A. Collins, Chwanrow K. Baban, Gerald C. O'Sullivan, Mark Tangney
Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jr. Laboratory, University College Cork, Cork, Ireland
Ali R. Akin, Jeff Meganck, Jae-Beom Kim, Ning Zhang, Kevin P. Francis
Caliper – a PerkinElmer Company, Alameda, California, United States of America
Sara A. Collins, Noriyuki Kasahara, Mark Tangney
School of Medicine, University of California Los Angeles, Los Angeles, California, United State of America
Susan A. Joyce, Douwe van Sinderen, Cormac G. Gahan
Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
Gooitzen M. van Dam
Department of Surgery, Division of Surgical Oncology, BioOptical Imaging Center, University of Groningen, Groningen, The Netherlands
Cormac G. Gahan
School of Pharmacy, University College Cork, Cork, Ireland

Corresponding Author

Email: m.tangney@ucc.ie

Competing Interests

AA, JM, J-BK, NZ and KF are employees of Caliper Life Sciences. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MT KF. Performed the experiments: MC AA SC J-BK CB. Analyzed the data: JM. Contributed reagents/materials/analysis tools: SJ DvS NZ NK CG GO GvD. Wrote the paper: MT MC.