About the Authors

Mary F. Kearney

kearneym@mail.nih.gov

Affiliation HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, United States of America

Jonathan Spindler

Affiliation HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, United States of America

Ann Wiegand

Affiliation HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, United States of America

Wei Shao

Affiliation Advanced Biomedical Computing Center, SAIC, Frederick, Maryland, United States of America

Elizabeth M. Anderson

Affiliation HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, United States of America

Frank Maldarelli

Affiliation HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, United States of America

Francis W. Ruscetti

Affiliation Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland, United States of America

John W. Mellors

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Steve H. Hughes

Affiliation HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, United States of America

Stuart F. J. Le Grice

Affiliation HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, United States of America

John M. Coffin

Affiliation Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, United States of America

Competing Interests

Dr. Mellors is a consultant for Gilead Sciences, Merck, and RFS Pharma and owns share options in RFS Pharma. Dr. Shao is an employee of SIAC, Frederick. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MK JMC. Performed the experiments: MK AW JS FR. Analyzed the data: MK JS AW JMC WS EA. Contributed reagents/materials/analysis tools: FM SL FR. Wrote the paper: MK JMC JWM SH.