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Research Article

Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models

  • Li Shen,

    Affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Michael Ciesielski,

    Affiliation: Department of Neuro-Oncology, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Swathi Ramakrishnan,

    Affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Kiersten M. Miles,

    Affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Leigh Ellis,

    Affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Paula Sotomayor,

    Affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Protul Shrikant,

    Affiliation: Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Robert Fenstermaker,

    Affiliation: Department of Neuro-Oncology, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Roberto Pili mail

    Roberto.Pili@RoswellPark.org

    Affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Published: January 27, 2012
  • DOI: 10.1371/journal.pone.0030815

About the Authors

Li Shen, Swathi Ramakrishnan, Kiersten M. Miles, Leigh Ellis, Paula Sotomayor, Roberto Pili
Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Michael Ciesielski, Robert Fenstermaker
Department of Neuro-Oncology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Protul Shrikant
Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, United States of America

Corresponding Author

Email: Roberto.Pili@RoswellPark.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LS MC P.Shrikant RF RP. Performed the experiments: LS MC SR KMM LE P.Sotomayor. Analyzed the data: LS MC LE P.Sotomayor RF RP. Contributed reagents/materials/analysis tools: RF RP. Wrote the paper: LS MC RP.