About the Authors

Robert Mintzer

Affiliation Department of Biochemical Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

Sreemathy Ramaswamy

Affiliation Department of Biochemical Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

Kinjalkumar Shah

Affiliation Department of Biochemical Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

Rami N. Hannoush

Affiliation Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, California, United States of America

Christine D. Pozniak

Affiliation Department of Neuroscience, Genentech, Inc., South San Francisco, California, United States of America

Frederick Cohen

Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America

Xianrui Zhao

Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America

Emile Plise

Affiliation Department of Drug Metabolism and PK, Genentech, Inc., South San Francisco, California, United States of America

Joseph W. Lewcock

Affiliation Department of Neuroscience, Genentech, Inc., South San Francisco, California, United States of America

Christopher E. Heise

heise.christopher@gene.com

Affiliation Department of Biochemical Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

Competing Interests

All authors are full-time employees of Genentech. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. There are no patents, products in development, or marketed products to declare.

Author Contributions

Conceived and designed the experiments: RM SR RNH CEH. Performed the experiments: RM SR KS RNH EP. Analyzed the data: RM SR RNH CEH. Contributed reagents/materials/analysis tools: CDP XZ FC JWL. Wrote the paper: RM CEH.