About the Authors

Pericles Calias

Contributed equally to this work with: Pericles Calias, Mikhail Papisov

pcalias@shire.com

Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

Mikhail Papisov

Contributed equally to this work with: Pericles Calias, Mikhail Papisov

Affiliations Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Radiology, Harvard Medical School, Cambridge, Massachusetts, United States of America, Department of Nuclear Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America

Jing Pan

Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

Nancy Savioli

Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

Vasily Belov

Affiliations Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Radiology, Harvard Medical School, Cambridge, Massachusetts, United States of America, Department of Nuclear Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America

Yan Huang

Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

Jason Lotterhand

Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

Mary Alessandrini

Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

Nan Liu

Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

Alan J. Fischman

Affiliations Department of Radiology, Harvard Medical School, Cambridge, Massachusetts, United States of America, Department of Nuclear Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America

Jan L. Powell

Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

Michael W. Heartlein

Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: PC, JP, YH, MA, NL, NS, JL, JLP and MWH are full-time employees of Shire Human Genetic Therapies, Inc. MP, VB and AJF have no competing interests to declare. This does not alter the authors′ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PC MP. Performed the experiments: JP YH MA NL NS JL MP VB AJF. Analyzed the data: PC MP JLP JP. Wrote the paper: PC MP JLP JP. Provided intellectual support and conceptual advice: MWH. Critically reviewed and provided revisions to the manuscript content: NS VB YH JL MA NL AJF MWH.