About the Authors

Marcus O. Butler

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Osamu Imataki

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Yoshihiro Yamashita

Affiliation Division of Functional Genomics, Jichi Medical University, Tochigi, Japan

Makito Tanaka

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Sascha Ansén

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Alla Berezovskaya

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States of America

Genita Metzler

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States of America

Matthew I. Milstein

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States of America

Mary M. Mooney

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States of America

Andrew P. Murray

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States of America

Hiroyuki Mano

Affiliations Division of Functional Genomics, Jichi Medical University, Tochigi, Japan, Department of Medical Genomics, University of Tokyo, Tokyo, Japan

Lee M. Nadler

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Naoto Hirano

nhirano@uhnres.utoronto.ca

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Immune Therapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Immunology, University of Toronto, Toronto, Ontario, Canada

Competing Interests

MOB, LMN and NH have filed a patent application related to aAPC/A2. The patent application number is 10/850,294 and is entitled, "Modified Antigen-Presenting Cells." The authors confirm that this application does not alter their adherence to all PLoS ONE policies on the sharing of data and materials.

Author Contributions

Conceived and designed the experiments: MOB LMN NH. Performed the experiments: MOB OI MT SA AB GM MIM MMM APM NH. Analyzed the data: MOB LMN NH. Contributed reagents/materials/analysis tools: MOB OI YY MT SA HM LMN NH. Wrote the paper: MOB LMN NH.