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Research Article

PGC-1α Induces Mitochondrial and Myokine Transcriptional Programs and Lipid Droplet and Glycogen Accumulation in Cultured Human Skeletal Muscle Cells

  • Emma Mormeneo mail,

    emormeneo@ub.edu

    Affiliations: CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain, Departament de Bioquímica i Biologia Molecular, IBUB, Universitat de Barcelona (UB), Barcelona, Spain

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  • Cecilia Jimenez-Mallebrera,

    Affiliation: Unitat de Patologia Neuromuscular, Servei de Neurologia, Hospital Sant Joan de Déu, Barcelona, Spain

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  • Xavier Palomer,

    Affiliations: CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain, Departament de Farmacologia i Química Terapèutica, IBUB, Universitat de Barcelona (UB), Barcelona, Spain

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  • Valeria De Nigris,

    Affiliation: Diabetes and Obesity Laboratory, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona; Spain

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  • Manuel Vázquez-Carrera,

    Affiliations: CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain, Departament de Farmacologia i Química Terapèutica, IBUB, Universitat de Barcelona (UB), Barcelona, Spain

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  • Anna Orozco,

    Affiliations: CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain, Departament de Bioquímica i Biologia Molecular, IBUB, Universitat de Barcelona (UB), Barcelona, Spain

    X
  • Andrés Nascimento,

    Affiliation: Unitat de Patologia Neuromuscular, Servei de Neurologia, Hospital Sant Joan de Déu, Barcelona, Spain

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  • Jaume Colomer,

    Affiliation: Unitat de Patologia Neuromuscular, Servei de Neurologia, Hospital Sant Joan de Déu, Barcelona, Spain

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  • Carles Lerín,

    Affiliations: CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain, Diabetes and Obesity Laboratory, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona; Spain

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  • Anna M. Gómez-Foix

    Affiliations: CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain, Departament de Bioquímica i Biologia Molecular, IBUB, Universitat de Barcelona (UB), Barcelona, Spain

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  • Published: January 17, 2012
  • DOI: 10.1371/journal.pone.0029985

About the Authors

Emma Mormeneo, Xavier Palomer, Manuel Vázquez-Carrera, Anna Orozco, Carles Lerín, Anna M. Gómez-Foix
CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Barcelona, Spain
Emma Mormeneo, Anna Orozco, Anna M. Gómez-Foix
Departament de Bioquímica i Biologia Molecular, IBUB, Universitat de Barcelona (UB), Barcelona, Spain
Cecilia Jimenez-Mallebrera, Andrés Nascimento, Jaume Colomer
Unitat de Patologia Neuromuscular, Servei de Neurologia, Hospital Sant Joan de Déu, Barcelona, Spain
Xavier Palomer, Manuel Vázquez-Carrera
Departament de Farmacologia i Química Terapèutica, IBUB, Universitat de Barcelona (UB), Barcelona, Spain
Valeria De Nigris, Carles Lerín
Diabetes and Obesity Laboratory, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona; Spain

Corresponding Author

Email: emormeneo@ub.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EM AMG-F CL. Performed the experiments: EM XP AO VDN. Analyzed the data: EM AMG-F CL CJ-M. Contributed reagents/materials/analysis tools: CJ-M MV-C AN JC. Wrote the paper: EM AMG-F MV-C CL.