About the Authors

Paola Sebastiani

sebas@bu.edu

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Nadia Solovieff

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Andrew T. DeWan

Affiliation Division of Chronic Disease Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America

Kyle M. Walsh

Affiliation Division of Chronic Disease Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America

Annibale Puca

Affiliation IRCCS Multimedica, Milano, Italy; Istituto di Tecnologie Biomediche – Consiglio Nazionale delle Ricerche, Segrate, Italy

Stephen W. Hartley

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Efthymia Melista

Affiliation Center for Human Genetics, Boston University School of Medicine, Boston, Massachusetts, United States of America

Stacy Andersen

Affiliation Section of Geriatrics, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America

Daniel A. Dworkis

Affiliation Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

Jemma B. Wilk

Affiliation Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

Richard H. Myers

Affiliation Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

Martin H. Steinberg

Affiliation Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

Monty Montano

Affiliation Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

Clinton T. Baldwin

Affiliations Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, Departments of Medicine and Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America

Josephine Hoh

Affiliation Division of Chronic Disease Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America

Thomas T. Perls

Affiliation Section of Geriatrics, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America

Competing Interests

In the study the authors included 254 subjects enrolled at ELIXIR. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PS CB MS MM JH TP. Performed the experiments: CB EM AD KW JH. Analyzed the data: PS NS SH DD AD KW JH. Contributed reagents/materials/analysis tools: AP JW RM SA. Wrote the paper: PS NS MS MM JH TP.