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Research Article

Genetic Signatures of Exceptional Longevity in Humans

  • Paola Sebastiani mail,

    sebas@bu.edu

    Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Nadia Solovieff,

    Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Andrew T. DeWan,

    Affiliation: Division of Chronic Disease Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • Kyle M. Walsh,

    Affiliation: Division of Chronic Disease Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • Annibale Puca,

    Affiliation: IRCCS Multimedica, Milano, Italy; Istituto di Tecnologie Biomediche – Consiglio Nazionale delle Ricerche, Segrate, Italy

    X
  • Stephen W. Hartley,

    Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Efthymia Melista,

    Affiliation: Center for Human Genetics, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Stacy Andersen,

    Affiliation: Section of Geriatrics, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America

    X
  • Daniel A. Dworkis,

    Affiliation: Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Jemma B. Wilk,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Richard H. Myers,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Martin H. Steinberg,

    Affiliation: Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Monty Montano,

    Affiliation: Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Clinton T. Baldwin,

    Affiliations: Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, Departments of Medicine and Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America

    X
  • Josephine Hoh,

    Affiliation: Division of Chronic Disease Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • Thomas T. Perls

    Affiliation: Section of Geriatrics, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America

    X
  • Published: January 18, 2012
  • DOI: 10.1371/journal.pone.0029848

About the Authors

Paola Sebastiani, Nadia Solovieff, Stephen W. Hartley
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
Andrew T. DeWan, Kyle M. Walsh, Josephine Hoh
Division of Chronic Disease Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America
Annibale Puca
IRCCS Multimedica, Milano, Italy; Istituto di Tecnologie Biomediche – Consiglio Nazionale delle Ricerche, Segrate, Italy
Efthymia Melista
Center for Human Genetics, Boston University School of Medicine, Boston, Massachusetts, United States of America
Stacy Andersen, Thomas T. Perls
Section of Geriatrics, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America
Daniel A. Dworkis, Martin H. Steinberg, Monty Montano, Clinton T. Baldwin
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
Jemma B. Wilk, Richard H. Myers
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
Clinton T. Baldwin
Departments of Medicine and Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America

Corresponding Author

Email: sebas@bu.edu

Competing Interests

In the study the authors included 254 subjects enrolled at ELIXIR. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PS CB MS MM JH TP. Performed the experiments: CB EM AD KW JH. Analyzed the data: PS NS SH DD AD KW JH. Contributed reagents/materials/analysis tools: AP JW RM SA. Wrote the paper: PS NS MS MM JH TP.