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Research Article

CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control

  • Beatriz Mothe,

    Affiliations: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Lluita contra la Sida' Foundation, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Universitat Autònoma de Barcelona, Barcelona, Spain

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  • Anuska Llano,

    Affiliation: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Javier Ibarrondo,

    Affiliation: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

    Current address: University of California, Los Angeles, Los Angeles, California, United States of America

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  • Jennifer Zamarreño,

    Affiliation: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Mattia Schiaulini,

    Affiliations: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Universitat Autònoma de Barcelona, Barcelona, Spain

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  • Cristina Miranda,

    Affiliation: Lluita contra la Sida' Foundation, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Marta Ruiz-Riol,

    Affiliation: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Christoph T. Berger,

    Affiliation: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America

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  • M. José Herrero,

    Affiliation: Department of Immunology, LIRAD-Banc de Sang i Teixits, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Eduard Palou,

    Affiliation: Department of Immunology, LIRAD-Banc de Sang i Teixits, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Montse Plana,

    Affiliation: AIDS Research Group-IDIBAPS, Hospital Clinic, HIVACAT, University of Barcelona, Barcelona, Spain

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  • Morgane Rolland,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    Current address: HIV Military Research Program, Rockville, Maryland, United States of America

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  • Ashok Khatri,

    Affiliation: Massachusetts General Hospital, Peptide/Protein Core Facility, Boston, Massachusetts, United States of America

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  • David Heckerman,

    Affiliation: Microsoft Research, Redmond, Washington, United States of America

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  • Florencia Pereyra,

    Affiliation: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America

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  • Bruce D. Walker,

    Affiliations: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • David Weiner,

    Affiliation: University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Roger Paredes,

    Affiliations: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Lluita contra la Sida' Foundation, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Bonaventura Clotet,

    Affiliations: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Lluita contra la Sida' Foundation, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Barbara K. Felber,

    Affiliation: NCI-Frederick, Frederick, Maryland, United States of America

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  • George N. Pavlakis,

    Affiliation: NCI-Frederick, Frederick, Maryland, United States of America

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  • James I. Mullins,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Christian Brander mail

    cbrander@irsicaixa.es

    Affiliations: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

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  • Published: January 04, 2012
  • DOI: 10.1371/journal.pone.0029717

About the Authors

Beatriz Mothe, Anuska Llano, Javier Ibarrondo, Jennifer Zamarreño, Mattia Schiaulini, Marta Ruiz-Riol, Roger Paredes, Bonaventura Clotet, Christian Brander
IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
Beatriz Mothe, Cristina Miranda, Roger Paredes, Bonaventura Clotet
Lluita contra la Sida' Foundation, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
Beatriz Mothe, Mattia Schiaulini
Universitat Autònoma de Barcelona, Barcelona, Spain
Christoph T. Berger, Florencia Pereyra, Bruce D. Walker
Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America
M. José Herrero, Eduard Palou
Department of Immunology, LIRAD-Banc de Sang i Teixits, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
Montse Plana
AIDS Research Group-IDIBAPS, Hospital Clinic, HIVACAT, University of Barcelona, Barcelona, Spain
Morgane Rolland, James I. Mullins
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
Ashok Khatri
Massachusetts General Hospital, Peptide/Protein Core Facility, Boston, Massachusetts, United States of America
David Heckerman
Microsoft Research, Redmond, Washington, United States of America
Bruce D. Walker
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
David Weiner
University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Barbara K. Felber, George N. Pavlakis
NCI-Frederick, Frederick, Maryland, United States of America
Christian Brander
Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

Corresponding Author

Email: cbrander@irsicaixa.es

Competing Interests

DH is employed by Microsoft Research. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Performed the experiments: BM AL JI JZ MS MRR CTB. Analyzed the data: BM CM CB. Contributed reagents/materials/analysis tools: MJH EP AK DH MR FP BW DW BF GP. Wrote the paper: BM JM BC RP MP CB. Reviewed the final manuscript: BC.