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Research Article

Prediction of High-Grade Vesicoureteral Reflux after Pediatric Urinary Tract Infection: External Validation Study of Procalcitonin-Based Decision Rule

  • Sandrine Leroy mail,

    Sandrine.Leroy @pasteur.fr

    Affiliations: Centre for Statistics in Medicine, Oxford, United Kingdom, Epidemiology of Emerging Diseases Unit, Institut Pasteur, Paris, France, Inserm U953 Unit, Paris, France, Department of Pediatrics, Paris Descartes University, Necker Hospital, AP-HP, Paris, France

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  • François Bouissou,

    Affiliation: Department of Pediatrics, Children's Hospital, Paul Sabathier University, CHU Purpan, Toulouse, France

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  • Anna Fernandez-Lopez,

    Affiliation: Department of Pediatrics, Hospital Universitari Arnau de Vilanova, Lleida. Spain

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  • Metin K. Gurgoze,

    Affiliation: Firat University Faculty of Medicine, Elazig, Turkey

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  • Kyriaki Karavanaki,

    Affiliation: Department of Nephrology "A. and P. Kyriakou" Childen's Hospital, Athens, Greece

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  • Tim Ulinski,

    Affiliation: Department of Pediatric Nephrology, Trousseau Hospital and University Pierre et Marie Curie, Paris, France

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  • Silvia Bressan,

    Affiliation: Department of Pediatrics, University of Padova, Padova, Italy

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  • Geogios Vaos,

    Affiliation: Department of Pediatric Surgery, Alexandroupolis University Hospital, Thrace, Greece

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  • Pierre Leblond,

    Affiliation: Department of Pediatrics, Jeanne de Flandre Hospital, Lille, France

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  • Yvon Coulais,

    Affiliation: Department of Pediatrics, Children's Hospital, Paul Sabathier University, CHU Purpan, Toulouse, France

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  • Carlos Luaces Cubells,

    Affiliation: Department of Pediatrics, Hospital San Joan de Déu., Barcelona, Spain

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  • A. Denizmen Aygun,

    Affiliation: Firat University Faculty of Medicine, Elazig, Turkey

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  • Constantinos J. Stefanidis,

    Affiliation: Department of Nephrology "A. and P. Kyriakou" Childen's Hospital, Athens, Greece

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  • Albert Bensman,

    Affiliation: Department of Pediatric Nephrology, Trousseau Hospital and University Pierre et Marie Curie, Paris, France

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  • Liviana DaDalt,

    Affiliation: Department of Pediatrics, University of Padova, Padova, Italy

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  • Stefanos Gardikis,

    Affiliation: Department of Pediatric Surgery, Alexandroupolis University Hospital, Thrace, Greece

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  • Sandra Bigot,

    Affiliation: Department of Pediatrics, Jeanne de Flandre Hospital, Lille, France

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  • Dominique Gendrel,

    Affiliation: Department of Pediatrics, Paris Descartes University, Necker Hospital, AP-HP, Paris, France

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  • Gérard Bréart,

    Affiliation: Inserm U953 Unit, Paris, France

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  • Martin Chalumeau

    Affiliations: Inserm U953 Unit, Paris, France, Department of Pediatrics, Paris Descartes University, Necker Hospital, AP-HP, Paris, France

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  • Published: December 28, 2011
  • DOI: 10.1371/journal.pone.0029556

About the Authors

Sandrine Leroy
Centre for Statistics in Medicine, Oxford, United Kingdom
Sandrine Leroy
Epidemiology of Emerging Diseases Unit, Institut Pasteur, Paris, France
Sandrine Leroy, Gérard Bréart, Martin Chalumeau
Inserm U953 Unit, Paris, France
Sandrine Leroy, Dominique Gendrel, Martin Chalumeau
Department of Pediatrics, Paris Descartes University, Necker Hospital, AP-HP, Paris, France
François Bouissou, Yvon Coulais
Department of Pediatrics, Children's Hospital, Paul Sabathier University, CHU Purpan, Toulouse, France
Anna Fernandez-Lopez
Department of Pediatrics, Hospital Universitari Arnau de Vilanova, Lleida. Spain
Metin K. Gurgoze, A. Denizmen Aygun
Firat University Faculty of Medicine, Elazig, Turkey
Kyriaki Karavanaki, Constantinos J. Stefanidis
Department of Nephrology "A. and P. Kyriakou" Childen's Hospital, Athens, Greece
Tim Ulinski, Albert Bensman
Department of Pediatric Nephrology, Trousseau Hospital and University Pierre et Marie Curie, Paris, France
Silvia Bressan, Liviana DaDalt
Department of Pediatrics, University of Padova, Padova, Italy
Geogios Vaos, Stefanos Gardikis
Department of Pediatric Surgery, Alexandroupolis University Hospital, Thrace, Greece
Pierre Leblond, Sandra Bigot
Department of Pediatrics, Jeanne de Flandre Hospital, Lille, France
Carlos Luaces Cubells
Department of Pediatrics, Hospital San Joan de Déu., Barcelona, Spain

Corresponding Author

Email: Sandrine.Leroy @pasteur.fr

Competing Interests

Professors Gendrel and Chalumeau have received unrestricted educational grants for other studies, for a total amount lower than €5000, from Brahms AG, the manufacturer of procalcitonin, in 2007. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the study: SL MC. Collected the data: FB AF-L MKG KK TU SB GV PL YC CLC ADA CJS AB LD SG SB. Performed the statistical analysis: SL. Interpreted the data: SL. Drafted the manuscript: SL. Critically revised the manuscript for important intellectual content: SL FB AF-L MKG KK TU SB GV PL YC CLC ADA CJS AB LD SG SB DG GB MC. Brought expertise in Epidemiology and Pediatric Infecious Diseses, respectively: GB DG. Obtained funding: SL.