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Research Article

CAG Repeat Variants in the POLG1 Gene Encoding mtDNA Polymerase-Gamma and Risk of Breast Cancer in African-American Women

  • Sami Azrak,

    Affiliation: Department of Biological Sciences, Brock University, St. Catharine's, Ontario, Canada

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  • Vanniarajan Ayyasamy,

    Affiliation: Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Gary Zirpoli,

    Affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Christine Ambrosone,

    Affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Elisa V. Bandera,

    Affiliation: The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America

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  • Dana H. Bovbjerg,

    Affiliation: University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Lina Jandorf,

    Affiliation: Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Gregory Ciupak,

    Affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Warren Davis,

    Affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America

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  • Karen S. Pawlish,

    Affiliation: New Jersey State Cancer Registry, New Jersey Department of Health & Senior Services, Trenton, New Jersey, United States of America

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  • Ping Liang,

    Affiliation: Department of Biological Sciences, Brock University, St. Catharine's, Ontario, Canada

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  • Keshav Singh mail

    kksingh@uab.edu

    Affiliations: Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, United States of America, Departments of Genetics, Pathology, Environmental Health, Center for Free Radical Biology, Center for Aging and UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Published: January 20, 2012
  • DOI: 10.1371/journal.pone.0029548

About the Authors

Sami Azrak, Ping Liang
Department of Biological Sciences, Brock University, St. Catharine's, Ontario, Canada
Vanniarajan Ayyasamy, Keshav Singh
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Gary Zirpoli, Christine Ambrosone, Gregory Ciupak, Warren Davis
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Elisa V. Bandera
The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America
Dana H. Bovbjerg
University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Lina Jandorf
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
Karen S. Pawlish
New Jersey State Cancer Registry, New Jersey Department of Health & Senior Services, Trenton, New Jersey, United States of America
Keshav Singh
Departments of Genetics, Pathology, Environmental Health, Center for Free Radical Biology, Center for Aging and UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Corresponding Author

Email: kksingh@uab.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CA PL KS. Performed the experiments: SA VA. Analyzed the data: SA GZ GC WD PL. Contributed reagents/materials/analysis tools: EVB DHB LJ KSP. Wrote the paper: VA CA PL KS.