About the Authors

Sandra Kirsch Heibel

Affiliations Center for Genetic Medicine Research, Children's National Medical Center, Washington, D. C., United States of America, Molecular and Cellular Biology Program, University of Maryland, College Park, Maryland, United States of America

Giselle Yvette Lopez

Affiliation Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America

Maria Panglao

Affiliation The George Washington University School of Medicine and Health Sciences, Washington, D. C., United States of America

Sonal Sodha

Affiliation Johns Hopkins School of Medicine in Baltimore, Maryland, United States of America

Leonardo Mariño-Ramírez

Affiliation Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America

Mendel Tuchman

Affiliation Center for Genetic Medicine Research, Children's National Medical Center, Washington, D. C., United States of America

Ljubica Caldovic

ljubica@cnmcresearch.org

Affiliation Center for Genetic Medicine Research, Children's National Medical Center, Washington, D. C., United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Analyzed the data: SKH. Contributed reagents/materials/analysis tools: LM-R. Wrote the paper: SKH. Designed the experiments: SKH. Critically reviewed the manuscript: MT. Conceived the study and reviewed the manuscript: LC. Performed reporter assays, 5′-RACE, DNA pill-down assays, ChIP, bioinformatic analysis and wrote the paper: SKH. Carried out and analyzed bioinformatic analysis of the NAGS upstream regulatory region: GYL MP SS LM-R.