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Research Article

Activity-Induced Remodeling of Olfactory Bulb Microcircuits Revealed by Monosynaptic Tracing

  • Benjamin R. Arenkiel mail,

    arenkiel@bcm.edu (BRA); michael.ehlers@pfizer.com (MDE)

    Affiliations: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, United States of America, Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America

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  • Hiroshi Hasegawa,

    Affiliation: Department of Cell Biology, Duke University, Durham, North Carolina, United States of America

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  • Jason J. Yi,

    Affiliation: Department of Neurobiology, Duke University, Durham, North Carolina, United States of America

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  • Rylan S. Larsen,

    Affiliation: Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Michael L. Wallace,

    Affiliation: Curriculum in Neurobiology, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Benjamin D. Philpot,

    Affiliations: Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Curriculum in Neurobiology, University of North Carolina, Chapel Hill, North Carolina, United States of America, UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Neurodevelopmental Disorders Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Fan Wang,

    Affiliations: Department of Cell Biology, Duke University, Durham, North Carolina, United States of America, Department of Neurobiology, Duke University, Durham, North Carolina, United States of America

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  • Michael D. Ehlers mail

    arenkiel@bcm.edu (BRA); michael.ehlers@pfizer.com (MDE)

    Affiliations: Department of Cell Biology, Duke University, Durham, North Carolina, United States of America, Department of Neurobiology, Duke University, Durham, North Carolina, United States of America, Neuroscience Research Unit, Pfizer Global Research and Development, Groton, Connecticut, United States of America

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  • Published: December 28, 2011
  • DOI: 10.1371/journal.pone.0029423

About the Authors

Benjamin R. Arenkiel
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
Benjamin R. Arenkiel
Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, United States of America
Hiroshi Hasegawa, Fan Wang, Michael D. Ehlers
Department of Cell Biology, Duke University, Durham, North Carolina, United States of America
Jason J. Yi, Fan Wang, Michael D. Ehlers
Department of Neurobiology, Duke University, Durham, North Carolina, United States of America
Rylan S. Larsen, Benjamin D. Philpot
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
Michael L. Wallace, Benjamin D. Philpot
Curriculum in Neurobiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
Benjamin D. Philpot
UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, United States of America
Benjamin D. Philpot
Neurodevelopmental Disorders Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America
Michael D. Ehlers
Neuroscience Research Unit, Pfizer Global Research and Development, Groton, Connecticut, United States of America
Benjamin R. Arenkiel
Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America

Corresponding Authors

Competing Interests

MDE is an employee of Pfizer, Inc. This does not alter the authors′ adherence to all the PLoS ONE policies on sharing data and materials..

Author Contributions

Conceived and designed the experiments: BRA MDE. Performed the experiments: BRA JJY RSL MLW. Analyzed the data: BRA JJY RSL MLW. Contributed reagents/materials/analysis tools: BRA BDP FW MDE HH. Wrote the paper: BRA MDE.