Vitamin D3 Deficiency Differentially Affects Functional and Disease Outcomes in the G93A Mouse Model of Amyotrophic Lateral Sclerosis

Jesse A. Solomon; Alexandro Gianforcaro; Mazen J. Hamadeh

doi:10.1371/journal.pone.0029354

Loading metrics

Open Access

Peer-reviewed

Research Article

Vitamin D₃ Deficiency Differentially Affects Functional and Disease Outcomes in the G93A Mouse Model of Amyotrophic Lateral Sclerosis

Jesse A. Solomon,

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada
⨯
Alexandro Gianforcaro,

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada
⨯
Mazen J. Hamadeh

* E-mail: hamadeh@yorku.ca

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
⨯

Vitamin D₃ Deficiency Differentially Affects Functional and Disease Outcomes in the G93A Mouse Model of Amyotrophic Lateral Sclerosis

Jesse A. Solomon,
Alexandro Gianforcaro,
Mazen J. Hamadeh

Published: December 27, 2011
https://doi.org/10.1371/journal.pone.0029354

About the Authors

Jesse A. Solomon

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada

Alexandro Gianforcaro

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada

Mazen J. Hamadeh

* E-mail: hamadeh@yorku.ca

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MJH JAS. Performed the experiments: JAS AG MJH. Analyzed the data: JAS. Contributed reagents/materials/analysis tools: MJH. Wrote the paper: JAS MJH.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Vitamins
Is the Subject Area "Vitamins" applicable to this article?

Thanks for your feedback.
Diet
Is the Subject Area "Diet" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Body weight
Is the Subject Area "Body weight" applicable to this article?

Thanks for your feedback.
Calcitriol
Is the Subject Area "Calcitriol" applicable to this article?

Thanks for your feedback.
Animal performance
Is the Subject Area "Animal performance" applicable to this article?

Thanks for your feedback.
Vitamin D
Is the Subject Area "Vitamin D" applicable to this article?

Thanks for your feedback.
Vitamin D deficiency
Is the Subject Area "Vitamin D deficiency" applicable to this article?

Thanks for your feedback.