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Research Article

Stretch-Induced Hypertrophy Activates NFkB-Mediated VEGF Secretion in Adult Cardiomyocytes

  • Anna Leychenko,

    Affiliations: Department of Cell and Molecular Biology and Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America, Department of Molecular Bioscience and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

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  • Eugene Konorev,

    Affiliation: Pharmaceutical Sciences, University of Hawaii-Hilo College of Pharmacy, Hilo, Hawaii, United States of America

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  • Mayumi Jijiwa,

    Affiliation: Department of Cell and Molecular Biology and Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America

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  • Michelle L. Matter mail

    matter@hawaii.edu

    Affiliation: Department of Cell and Molecular Biology and Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America

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  • Published: December 13, 2011
  • DOI: 10.1371/journal.pone.0029055

About the Authors

Anna Leychenko, Mayumi Jijiwa, Michelle L. Matter
Department of Cell and Molecular Biology and Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America
Anna Leychenko
Department of Molecular Bioscience and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America
Eugene Konorev
Pharmaceutical Sciences, University of Hawaii-Hilo College of Pharmacy, Hilo, Hawaii, United States of America

Corresponding Author

Email: matter@hawaii.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MLM EK. Performed the experiments: AL EK. Analyzed the data: MLM EK AL MJ. Contributed reagents/materials/analysis tools: MLM. Wrote the paper: MLM AL. Performed research: MJ.