Protein Kinase A Regulates Molecular Chaperone Transcription and Protein Aggregation

Yue Zhang; Ayesha Murshid; Thomas Prince; Stuart K. Calderwood

doi:10.1371/journal.pone.0028950

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Open Access

Peer-reviewed

Research Article

Protein Kinase A Regulates Molecular Chaperone Transcription and Protein Aggregation

Yue Zhang ,

Contributed equally to this work with: Yue Zhang, Ayesha Murshid

Affiliation Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Ayesha Murshid ,

Contributed equally to this work with: Yue Zhang, Ayesha Murshid

Affiliation Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Thomas Prince,

Affiliation Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Stuart K. Calderwood

* E-mail: scalderw@bidmc.harvard.edu

Affiliation Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Protein Kinase A Regulates Molecular Chaperone Transcription and Protein Aggregation

Yue Zhang,
Ayesha Murshid,
Thomas Prince,
Stuart K. Calderwood

Published: December 22, 2011
https://doi.org/10.1371/journal.pone.0028950

About the Authors

Yue Zhang

Contributed equally to this work with: Yue Zhang, Ayesha Murshid

Affiliation Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Ayesha Murshid

Contributed equally to this work with: Yue Zhang, Ayesha Murshid

Affiliation Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Thomas Prince

Affiliation Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Stuart K. Calderwood

* E-mail: scalderw@bidmc.harvard.edu

Affiliation Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YZ AM TP SKC. Performed the experiments: AM YZ. Analyzed the data: AM YZ. Contributed reagents/materials/analysis tools: AM YZ TP. Wrote the paper: YZ AM TP SKC.

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Small interfering RNA
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Histones
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Immunoprecipitation
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Messenger RNA
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DNA transcription
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HeLa cells
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Heat shock response
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Confocal microscopy
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