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Research Article

Efficient Conversion of Astrocytes to Functional Midbrain Dopaminergic Neurons Using a Single Polycistronic Vector

  • Russell C. Addis mail,

    raddis@mail.med.upenn.edu

    Affiliation: Institute for Regenerative Medicine and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Fu-Chun Hsu,

    Affiliation: Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Rebecca L. Wright,

    Affiliation: Institute for Regenerative Medicine and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Marc A. Dichter,

    Affiliations: Mahoney Institute of Neurological Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Douglas A. Coulter,

    Affiliations: Mahoney Institute of Neurological Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Departments of Pediatrics and Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • John D. Gearhart

    Affiliation: Institute for Regenerative Medicine and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: December 09, 2011
  • DOI: 10.1371/journal.pone.0028719

About the Authors

Russell C. Addis, Rebecca L. Wright, John D. Gearhart
Institute for Regenerative Medicine and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Marc A. Dichter, Douglas A. Coulter
Mahoney Institute of Neurological Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Marc A. Dichter
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Douglas A. Coulter
Departments of Pediatrics and Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Fu-Chun Hsu, Douglas A. Coulter
Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: raddis@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RCA MAD DAC JDG. Performed the experiments: RCA F-CH RLW. Analyzed the data: RCA F-CH MAD DAC JDG. Contributed reagents/materials/analysis tools: RCA F-CH RLW. Wrote the paper: RCA.