About the Authors

Melissa L. Knothe Tate

knothetate@case.edu

Affiliations Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Mechanical & Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America

Hana Chang

Affiliation Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America

Shannon R. Moore

Affiliation Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America

Ulf R. Knothe

Affiliation Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio, United States of America

Competing Interests

MLKT has a patent pending for flow directing materials and systems [23: Knothe Tate ML, Anderson EJ (2009) Flow Directing Materials and Systems. U.S. Patent and Trademark Office Appl. No. US 2009/0053109.]; MLKT and URK have a provisional patent pending for the biologics-enhanced mechanoactive reconstruction sheet technology used in this study [24: Knothe Tate ML, Knothe U (2010) MechanoActive Sheets for Surgical Reconstruction Procedures, IDA, U.S. Patent and Trademark Office Provisional Patent Application No. 61311056] and a patent issued in the arena of composition and method to induce bone healing and repair [35: Knothe Tate ML,Knothe UR (February 1, 2011) Composition and method for inducing bone growth and healing. U.S. Patent No.: US 7,879,107 B2.]. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: MLKT URK. Performed the experiments: MLKT HC SRM URK. Analyzed the data: MLKT HC SRM URK. Wrote the paper: MLKT URK. Customized software used in anlysis: HC.