About the Authors

Russell J. H. Ryan

Ryan.Russell@mgh.harvard.edu

Affiliations Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America

Mai Nitta

Affiliation Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Darrell Borger

Affiliation Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Lawrence R. Zukerberg

Affiliation Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Judith A. Ferry

Affiliation Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Nancy Lee Harris

Affiliation Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

A. John Iafrate

Affiliation Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Bradley E. Bernstein

Affiliations Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Aliyah R. Sohani

Contributed equally to this work with: Aliyah R. Sohani, Long Phi Le

Affiliation Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Long Phi Le

Contributed equally to this work with: Aliyah R. Sohani, Long Phi Le

Affiliation Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Competing Interests

Dr. Iafrate submitted a patent application for SNaPshot tumor genotyping methods similar to those used in this study (United States provisional patent 12/799,415). This does not alter the authors′ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RJHR AJI BEB LPL. Performed the experiments: RJHR MN DB LPL. Analyzed the data: RJHR MN ARS LPL. Contributed reagents/materials/analysis tools: DB LRZ JAF NLH AJI BEB ARS. Wrote the paper: RJHR. Revised the manuscript: JAF ARS LPL. Reviewed, classified, and selected cases for inclusion in the study: LRZ JAF NLH ARS.