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Research Article

Children Who Acquire HIV Infection Perinatally Are at Higher Risk of Early Death than Those Acquiring Infection through Breastmilk: A Meta-Analysis

  • Renaud Becquet mail,

    Renaud.Becquet@isped.u-bordeaux2.fr

    Affiliations: Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 897, Centre de Recherche “Epidémiologie et Biostatistique”, Bordeaux, France, Institut de Santé Publique Epidémiologie Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France

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  • Milly Marston,

    Affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • François Dabis,

    Affiliations: Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 897, Centre de Recherche “Epidémiologie et Biostatistique”, Bordeaux, France, Institut de Santé Publique Epidémiologie Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France

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  • Lawrence H. Moulton,

    Affiliation: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Glenda Gray,

    Affiliation: Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Soweto, South Africa

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  • Hoosen M. Coovadia,

    Affiliation: HIV Management, Maternal, Adolescent and Child Unit, University of the Witwatersrand, Soweto, South Africa

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  • Max Essex,

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health AIDS Initiative, Boston, Massachusetts, United States of America

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  • Didier K. Ekouevi,

    Affiliation: PAC-CI program, ANRS site in Côte d'Ivoire, Abidjan, Côte d'Ivoire

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  • Debra Jackson,

    Affiliation: School of Public Health, University of the Western Cape, Cape Town, South Africa

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  • Anna Coutsoudis,

    Affiliation: Department of Paediatrics and Child Health, University of KwaZulu-Natal, South Africa

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  • Charles Kilewo,

    Affiliation: Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

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  • Valériane Leroy,

    Affiliations: Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 897, Centre de Recherche “Epidémiologie et Biostatistique”, Bordeaux, France, Institut de Santé Publique Epidémiologie Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France

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  • Stefan Z. Wiktor,

    Affiliation: RETRO-CI project, Centers for Disease Control and Prevention, Global HIV/AIDS Program, Abidjan, Côte d'Ivoire

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  • Ruth Nduati,

    Affiliation: Department of Pediatrics, University of Nairobi, Nairobi, Kenya

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  • Philippe Msellati,

    Affiliation: Service de Pédiatrie, CHU Sourô Sanou, Bobo Dioulasso, Burkina Faso

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  • Basia Zaba,

    Affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Peter D. Ghys,

    Affiliation: UNAIDS, Epidemiology and Analysis Division, Geneva, Switzerland

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  • Marie-Louise Newell,

    Affiliations: Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa, Centre for Paediatric Epidemiology and Biostatistics, University College London, Institute of Child Health, London, United Kingdom

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  • the UNAIDS Child survival group

    See the Acknowledgments section for the detailed constitution of the group.

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  • Published: February 23, 2012
  • DOI: 10.1371/journal.pone.0028510

About the Authors

Renaud Becquet, François Dabis, Valériane Leroy
Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 897, Centre de Recherche “Epidémiologie et Biostatistique”, Bordeaux, France
Renaud Becquet, François Dabis, Valériane Leroy
Institut de Santé Publique Epidémiologie Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France
Milly Marston, Basia Zaba
London School of Hygiene and Tropical Medicine, London, United Kingdom
Lawrence H. Moulton
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Glenda Gray
Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Soweto, South Africa
Hoosen M. Coovadia
HIV Management, Maternal, Adolescent and Child Unit, University of the Witwatersrand, Soweto, South Africa
Max Essex
Department of Immunology and Infectious Diseases, Harvard School of Public Health AIDS Initiative, Boston, Massachusetts, United States of America
Didier K. Ekouevi
PAC-CI program, ANRS site in Côte d'Ivoire, Abidjan, Côte d'Ivoire
Debra Jackson
School of Public Health, University of the Western Cape, Cape Town, South Africa
Anna Coutsoudis
Department of Paediatrics and Child Health, University of KwaZulu-Natal, South Africa
Charles Kilewo
Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
Stefan Z. Wiktor
RETRO-CI project, Centers for Disease Control and Prevention, Global HIV/AIDS Program, Abidjan, Côte d'Ivoire
Ruth Nduati
Department of Pediatrics, University of Nairobi, Nairobi, Kenya
Philippe Msellati
Service de Pédiatrie, CHU Sourô Sanou, Bobo Dioulasso, Burkina Faso
Peter D. Ghys
UNAIDS, Epidemiology and Analysis Division, Geneva, Switzerland
Marie-Louise Newell
Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa
Marie-Louise Newell
Centre for Paediatric Epidemiology and Biostatistics, University College London, Institute of Child Health, London, United Kingdom

Corresponding Author

Email: Renaud.Becquet@isped.u-bordeaux2.fr

Competing Interests

Co-author Marie-Louise Newell is an Academic Editor for PLoS ONE. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials..

Author Contributions

Conceived and designed the experiments: RB FD LM GG HMC ME DKE DJ AC CK VL SZW RN PM M-LN. Performed the experiments: RB FD LM GG HMC ME DKE DJ AC CK VL SZW RN PM M-LN. Analyzed the data: RB MM FD BZ PDG M-LN. Contributed reagents/materials/analysis tools: RB MM FD BZ PDG M-LN.