About the Authors

Hisashi Urushihara

Affiliation Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan

Yuko Doi

Affiliation Ain Pharmaciez Inc., Tokyo, Japan

Masaru Arai

Affiliation Kraft Inc., Tokyo, Japan

Toshiyuki Matsunaga

Affiliation Kraft Inc., Tokyo, Japan

Yosuke Fujii

Affiliation Ain Pharmaciez Inc., Tokyo, Japan

Naoko Iino

Affiliation Department of Clinical Research and Informatics, Research Institute National Center for Global Health and Medicine, Tokyo, Japan

Takashi Kawamura

Affiliation Department of Preventive Service, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan

Koji Kawakami

kawakami.koji.4e@kyoto-u.ac.jp

Affiliation Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan

Competing Interests

HU has been a consultant for Eli Lilly Japan. KK, YD and YF are full-time employees of Ain Pharmaciez Inc. MA and TM are full-time employees of Kraft Inc. The remaining authors declare that no competing interests exist. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HU YD KK. Analyzed the data: HU TK KK. Wrote the paper: HU YD MA TM YF NI. Acquisition of data: HU YD MA TM YF NI Critical revision of the manuscript for important intellectual content: HU TK KK.