Concanavalin A/IFN-Gamma Triggers Autophagy-Related Necrotic Hepatocyte Death through IRGM1-Mediated Lysosomal Membrane Disruption

Chih-Peng Chang; Ming-Chen Yang; Huan-Yao Lei

doi:10.1371/journal.pone.0028323

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Open Access

Peer-reviewed

Research Article

Concanavalin A/IFN-Gamma Triggers Autophagy-Related Necrotic Hepatocyte Death through IRGM1-Mediated Lysosomal Membrane Disruption

Chih-Peng Chang,

Affiliations Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Infectious Disease and Signaling Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan
⨯
Ming-Chen Yang,

Affiliation Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
⨯
Huan-Yao Lei

* E-mail: hylei@mail.ncku.edu.tw

Affiliations Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Infectious Disease and Signaling Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan
⨯

Concanavalin A/IFN-Gamma Triggers Autophagy-Related Necrotic Hepatocyte Death through IRGM1-Mediated Lysosomal Membrane Disruption

Chih-Peng Chang,
Ming-Chen Yang,
Huan-Yao Lei

Published: December 5, 2011
https://doi.org/10.1371/journal.pone.0028323

About the Authors

Chih-Peng Chang

Affiliations Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Infectious Disease and Signaling Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Ming-Chen Yang

Affiliation Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Huan-Yao Lei

* E-mail: hylei@mail.ncku.edu.tw

Affiliations Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Infectious Disease and Signaling Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: C-PC H-YL. Performed the experiments: C-PC M-CY. Analyzed the data: C-PC. Contributed reagents/materials/analysis tools: H-YL. Wrote the paper: C-PC.

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Autophagic cell death
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Necrotic cell death
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Apoptosis
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Lysosomes
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Hepatoma cells
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Hepatocytes
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Necrosis
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Small interfering RNA
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