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Research Article

Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of γ-Secretase In Vivo

  • Tong Li mail,

    tli1@jhmi.edu

    Affiliation: Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America

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  • Yue-Ming Li,

    Affiliation: Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Kwangwook Ahn,

    Affiliation: Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Donald L. Price,

    Affiliations: Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America, Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America

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  • Sangram S. Sisodia,

    Affiliation: Department of Neurobiology, University of Chicago, Chicago, Illinois, United States of America

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  • Philip C. Wong

    Affiliations: Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America, Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America

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  • Published: November 29, 2011
  • DOI: 10.1371/journal.pone.0028179

About the Authors

Tong Li, Donald L. Price, Philip C. Wong
Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America
Donald L. Price, Philip C. Wong
Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America
Donald L. Price
Department of Neurology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America
Yue-Ming Li, Kwangwook Ahn
Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Sangram S. Sisodia
Department of Neurobiology, University of Chicago, Chicago, Illinois, United States of America

Corresponding Author

Email: tli1@jhmi.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TL Y-ML SSS DLP PCW. Performed the experiments: TL KA. Analyzed the data: TL Y-ML SSS DLP PCW. Wrote the paper: TL DLP PCW.