About the Authors

Mihaela Campan

Contributed equally to this work with: Mihaela Campan, Melissa Moffitt

Affiliation Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Melissa Moffitt

Contributed equally to this work with: Mihaela Campan, Melissa Moffitt

Affiliation Department of Obstetrics and Gynecology Division of Gynecologic Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Sahar Houshdaran

Affiliation Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Hui Shen

Affiliation University of Southern California Epigenome Center, University of Southern California, Los Angeles, CA, United States of America

Martin Widschwendter

Affiliation Department of Gynecological Oncology, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom

Günter Daxenbichler

Affiliation Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria

Tiffany Long

Affiliation Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Christian Marth

Affiliation Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria

Ite A. Laird-Offringa

Affiliations Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Michael F. Press

Affiliation Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Louis Dubeau

Affiliation Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Kimberly D. Siegmund

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Anna H. Wu

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Susan Groshen

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Uma Chandavarkar

Affiliation Department of Obstetrics and Gynecology Division of Gynecologic Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Lynda D. Roman

Affiliation Department of Obstetrics and Gynecology Division of Gynecologic Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Andrew Berchuck

Affiliation Department of Obstetrics and Gynecology Division of Gynecologic Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

Celeste L. Pearce

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Peter W. Laird

plaird@usc.edu

Affiliations Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, University of Southern California Epigenome Center, University of Southern California, Los Angeles, CA, United States of America

Competing Interests

PL is a consultant and Scientific Advisory Board member for Epigenomics AG. He holds issued patents on the MethyLight technology, which have been licensed to Epigenomics AG. This work was not supported by Epigenomics AG. Epigenomics had no role in study design, data collection or analysis, decision to publish, or preparation of the manuscript. In addition, PL and MC are named as inventors on a pending patent application for the Digital MethyLight technology. The patents and the relationship with Epigenomics do not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The other authors disclosed no potential competing interest.

Author Contributions

Conceived and designed the experiments: PL MW. Performed the experiments: MM MC SH TL UC. Analyzed the data: HS MC MM PL. Contributed reagents/materials/analysis tools: MW GD CM MP LD KS AW SG LR AB IL-O. Wrote the paper: MC MM PL. Discussed the results, commented, and edited the manuscript: GD IL-O LD LDR AB CP AW.