About the Authors
- Mihaela Campan
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Contributed equally to this work with: Mihaela Campan, Melissa Moffitt
Affiliation Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Melissa Moffitt
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Contributed equally to this work with: Mihaela Campan, Melissa Moffitt
Affiliation Department of Obstetrics and Gynecology Division of Gynecologic Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Sahar Houshdaran
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Affiliation Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Hui Shen
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Affiliation University of Southern California Epigenome Center, University of Southern California, Los Angeles, CA, United States of America
- Martin Widschwendter
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Affiliation Department of Gynecological Oncology, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom
- Günter Daxenbichler
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Affiliation Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
- Tiffany Long
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Affiliation Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Christian Marth
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Affiliation Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
- Ite A. Laird-Offringa
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Affiliations Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Michael F. Press
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Affiliation Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Louis Dubeau
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Affiliation Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Kimberly D. Siegmund
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Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Anna H. Wu
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Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Susan Groshen
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Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Uma Chandavarkar
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Affiliation Department of Obstetrics and Gynecology Division of Gynecologic Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Lynda D. Roman
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Affiliation Department of Obstetrics and Gynecology Division of Gynecologic Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Andrew Berchuck
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Affiliation Department of Obstetrics and Gynecology Division of Gynecologic Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
- Celeste L. Pearce
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Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Peter W. Laird
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* E-mail: plaird@usc.edu
Affiliations Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, University of Southern California Epigenome Center, University of Southern California, Los Angeles, CA, United States of America
Competing Interests
PL is a consultant and Scientific Advisory Board member for Epigenomics AG. He holds issued patents on the MethyLight technology, which have been licensed to Epigenomics AG. This work was not supported by Epigenomics AG. Epigenomics had no role in study design, data collection or analysis, decision to publish, or preparation of the manuscript. In addition, PL and MC are named as inventors on a pending patent application for the Digital MethyLight technology. The patents and the relationship with Epigenomics do not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The other authors disclosed no potential competing interest.
Author Contributions
Conceived and designed the experiments: PL MW. Performed the experiments: MM MC SH TL UC. Analyzed the data: HS MC MM PL. Contributed reagents/materials/analysis tools: MW GD CM MP LD KS AW SG LR AB IL-O. Wrote the paper: MC MM PL. Discussed the results, commented, and edited the manuscript: GD IL-O LD LDR AB CP AW.