About the Authors

Christopher K. McCann

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Gynecologic Oncology, Department of Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

Whitfield B. Growdon

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Gynecologic Oncology, Department of Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

Kashmira Kulkarni-Datar

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

Michael D. Curley

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

Anne M. Friel

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

Jennifer L. Proctor

Affiliation Infinity Pharmaceuticals, Cambridge, Massachusetts, United States of America

Hana Sheikh

Affiliation Infinity Pharmaceuticals, Cambridge, Massachusetts, United States of America

Igor Deyneko

Affiliation Infinity Pharmaceuticals, Cambridge, Massachusetts, United States of America

Jeanne A. Ferguson

Affiliation Infinity Pharmaceuticals, Cambridge, Massachusetts, United States of America

Vinod Vathipadiekal

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America

Michael J. Birrer

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America

Darrell R. Borger

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America

Gayatry Mohapatra

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America

Lawrence R. Zukerberg

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Rosemary Foster

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

John R. MacDougall

Affiliation Infinity Pharmaceuticals, Cambridge, Massachusetts, United States of America

Bo R. Rueda

brueda@partners.org

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Gynecologic Oncology, Department of Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

Jennifer L. Proctor, Hana Sheikh, Igor Deyneko, Jeanne A. Ferguson, and John R. MacDougall are employees of Infinity Pharmaceuticals. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BRR RF CKM WBG JRM DRB. Performed the experiments: WBG CKM MDC KK JLP ID VV AMF. Analyzed the data: CKM WBG KK MDC MJB VV JRM RF BRR LRZ. Contributed reagents/materials/analysis tools: HS JAF GM DRB. Wrote the paper: BRR RF CKM WBG.