About the Authors

Erika Suzuki

Affiliation Onyx Pharmaceuticals, South San Francisco, California, United States of America

Susan Demo

Affiliation Onyx Pharmaceuticals, South San Francisco, California, United States of America

Edgar Deu

Affiliation Stanford University, Stanford, California, United States of America

Jonathan Keats

Affiliation Translational Genomics Research Institute, Phoenix, Arizona, United States of America

Shirin Arastu-Kapur

Affiliation Onyx Pharmaceuticals, South San Francisco, California, United States of America

P. Leif Bergsagel

Affiliation Mayo Clinic, Scottsdale, Arizona, United States of America

Mark K. Bennett

Affiliation Onyx Pharmaceuticals, South San Francisco, California, United States of America

Christopher J. Kirk

ckirk@onyx-pharm.com

Affiliation Onyx Pharmaceuticals, South San Francisco, California, United States of America

Competing Interests

Christopher J. Kirk, Erika Suzuki and Shirin Arastu-Kapur are current employees of Onyx Pharmaceuticals. There are no patents to declare, however this study is in support of the mechanism of action of Carfilzomib, a product currently in development from Onyx. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MKB SD CJK ES SA-K ED JK. Performed the experiments: ES SA-K JK ED SD. Analyzed the data: ES SD JK SA-K MKB CJK. Contributed reagents/materials/analysis tools: PLB MKB CJK. Wrote the paper: SA-K ES CJK JK ED.