About the Authors

Kazuo Konishi

Contributed equally to this work with: Kazuo Konishi, Yoshiyuki Watanabe

konishimd@med.showa-u.ac.jp

Affiliations Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan

Yoshiyuki Watanabe

Contributed equally to this work with: Kazuo Konishi, Yoshiyuki Watanabe

Affiliations Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

Lanlan Shen

Affiliation Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Yi Guo

Affiliation Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Ryan J. Castoro

Affiliation Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Kimie Kondo

Affiliation Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Woonbok Chung

Affiliation Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Saira Ahmed

Affiliation Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Jaroslav Jelinek

Affiliation Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Yanis A. Boumber

Affiliation Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Marcos R. Estecio

Affiliation Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Shinji Maegawa

Affiliation Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Yutaka Kondo

Affiliation Division of Molecular Oncology, Aichi Cancer Center, Nagoya, Japan

Fumio Itoh

Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

Michio Imawari

Affiliation Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan

Stanley R. Hamilton

Affiliation Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Jean-Pierre J. Issa

Affiliation Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K.Konishi YW J-PI. Performed the experiments: K.Konishi YW LS YG RC K.Kondo WC SA JJ YB ME SM YK FI MI SH. Analyzed the data: K.Konishi YW J-PI. Contributed reagents/materials/analysis tools: K.Konishi YW LS SA JJ SH J-PI. Wrote the paper: K.Konishi J-PI.