About the Authors

Viktor von Wyl

Contributed equally to this work with: Viktor von Wyl, Sara Gianella, Marek Fischer

vowv@usz.uzh.ch

Affiliations Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland, Research Department of Infection and Population Health, University College London, London, United Kingdom

Sara Gianella

Contributed equally to this work with: Viktor von Wyl, Sara Gianella, Marek Fischer

Affiliations Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland, Division of Infectious Diseases, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Marek Fischer

Contributed equally to this work with: Viktor von Wyl, Sara Gianella, Marek Fischer

vowv@usz.uzh.ch

Affiliation Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland

Barbara Niederoest

Affiliation Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland

Herbert Kuster

Affiliation Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland

Manuel Battegay

Affiliation Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland

Enos Bernasconi

Affiliation Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland

Matthias Cavassini

Affiliation Division of Infectious Diseases and Hospital Epidemiology, University Hospital Lausanne, Lausanne, Switzerland

Andri Rauch

Affiliation University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Bern, Switzerland

Bernard Hirschel

Affiliation Division of Infectious Diseases, Geneva University Hospital, Geneva, Switzerland

Pietro Vernazza

Affiliation Division of Infectious Diseases, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

Rainer Weber

Affiliation Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland

Beda Joos

Affiliation Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland

Huldrych F. Günthard

Affiliation Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland

the Swiss HIV Cohort Study (SHCS)

Competing Interests

The authors delcare the following competing interest: HFG has been an advisor and consultant for GlaxoSmithKline (GSK), Abbott, Novartis, Boehringer Ingelheim, Roche, Tibotec, and Bristol-Myers Squibb (BMS) and has received unrestricted research and educational grants from Roche, Abbott, BMS, GSK, Tibotec, and Merck Sharp & Dohme (MSD) (all money to the institution). SY has participated in advisory boards of BMS and Tibotec and has received travel grants from GSK and MSD. MC has received travel grants from Abbott, Boehringer Ingelheim, and Gilead. EB has been an advisor and consultant for Gilead and Abbott, has been a member of an advisory board of ViiV, Gilead, Tibotec, Pfitzer, and MSD, and has received research grants from Gilead and Abbott as well as travel grants from BMS, Gilead, ViiV, MSD, Abbott, and Tibotec. PV has been a member of an advisory board of MSD, Tibotec, Gilead, and ViiV and has received payment for lectures from Gilead, Tibotec, and GSK. All the unrestricted research grants do not relate to the current study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors. All other authors report no potential conflicts.

Author Contributions

Conceived and designed the experiments: VvW SG MF BJ HFG. Performed the experiments: SG MF BJ HFG BN HK. Analyzed the data: VvW SG MF HFG. Wrote the paper: VvW SG MF BN HK MB AR EB BH RW HFG PV BJ MC. Enrolled Patients: MB AR EB BH RW PV MC HFG.