Characterization of the Response of Primary Cells Relevant to Dialysis-Related Amyloidosis to β2-Microglobulin Monomer and Fibrils

Morwenna Y. Porter; Katy E. Routledge; Sheena E. Radford; Eric W. Hewitt

doi:10.1371/journal.pone.0027353

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Open Access

Peer-reviewed

Research Article

Characterization of the Response of Primary Cells Relevant to Dialysis-Related Amyloidosis to β₂-Microglobulin Monomer and Fibrils

Morwenna Y. Porter,

Affiliation Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom
⨯
Katy E. Routledge,

Current address: Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

Affiliation Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom
⨯
Sheena E. Radford,

Affiliation Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom
⨯
Eric W. Hewitt

* E-mail: e.w.hewitt@leeds.ac.uk

Affiliation Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom
⨯

Characterization of the Response of Primary Cells Relevant to Dialysis-Related Amyloidosis to β₂-Microglobulin Monomer and Fibrils

Morwenna Y. Porter,
Katy E. Routledge,
Sheena E. Radford,
Eric W. Hewitt

Published: November 9, 2011
https://doi.org/10.1371/journal.pone.0027353

About the Authors

Morwenna Y. Porter

Affiliation Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom

Katy E. Routledge

Current address: Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

Affiliation Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom

Sheena E. Radford

Affiliation Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom

Eric W. Hewitt

* E-mail: e.w.hewitt@leeds.ac.uk

Affiliation Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MYP KER SER EWH. Performed the experiments: MYP KER. Analyzed the data: MYP KER SER EWH. Contributed reagents/materials/analysis tools: MYP. Wrote the paper: MYP KER SER EWH.

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Monocytes
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Osteoclasts
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Amyloid proteins
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Monomers
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Osteoblasts
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Chondrocytes
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Macrophages
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Cytotoxicity
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