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Research Article

Capsomer Vaccines Protect Mice from Vaginal Challenge with Human Papillomavirus

  • Wai-Hong Wu,

    Affiliation: Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Elizabeth Gersch,

    Affiliation: Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America

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  • Kihyuck Kwak,

    Affiliation: Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Subhashini Jagu,

    Affiliation: Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Balasubramanyam Karanam,

    Affiliation: Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Warner K. Huh,

    Affiliation: Department of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Robert L. Garcea,

    Affiliation: Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America

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  • Richard B. S. Roden mail

    roden@jhmi.edu

    Affiliations: Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Oncology, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Published: November 01, 2011
  • DOI: 10.1371/journal.pone.0027141

About the Authors

Wai-Hong Wu, Kihyuck Kwak, Subhashini Jagu, Balasubramanyam Karanam, Richard B. S. Roden
Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States of America
Elizabeth Gersch, Robert L. Garcea
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America
Warner K. Huh
Department of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Richard B. S. Roden
Department of Oncology, Johns Hopkins University, Baltimore, Maryland, United States of America
Richard B. S. Roden
Department of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland, United States of America

Corresponding Author

Email: roden@jhmi.edu

Competing Interests

SJ and RBSR are co-inventors on L2 patents licensed to Shantha Biotechnics Ltd., GlaxoSmithKline, PaxVax, Inc. and Acambis, Inc. The terms of these arrangements are managed by Johns Hopkins University in accordance with its conflict of interest policies. RLG has intellectual property concerning capsomer vaccines, managed by the University of Colorado Technology Transfer Office. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RBR RLG WKH. Performed the experiments: W-HW EG KK SJ BK. Analyzed the data: W-HW EG KK SJ BK RBR RLG WKH. Contributed reagents/materials/analysis tools: KK SJ BK. Wrote the paper: RBR RLG WKH.