About the Authors

Swati Biswas

swati.biswas@vanderbilt.edu

Affiliations Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Jeffry S. Nyman

Affiliation Department of Orthopedics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

JoAnn Alvarez

Affiliation Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Anwesa Chakrabarti

Affiliation Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Austin Ayres

Affiliation Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Julie Sterling

Affiliation Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

James Edwards

Affiliation Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Tapasi Rana

Affiliation Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Rachelle Johnson

Affiliation Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Daniel S. Perrien

Affiliations Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Orthopedics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Vanderbilt University Institute of Imaging Science, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Scott Lonning

Affiliation Genzyme Corporation, Framingham, Massachusetts, United States of America

Yu Shyr

Affiliation Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Lynn M. Matrisian

Affiliation Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Gregory R. Mundy

Affiliations Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Competing Interests

Scott Lonning is an employee of Genzyme Corporation who provided us with the anti-TGF beta antibody. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: SB JSN GRM. Performed the experiments: SB JSN AC AA TR. Analyzed the data: SB JSN JA YS AC. Contributed reagents/materials/analysis tools: JA JSN DSP SL RJ JS JE. Wrote the paper: SB JSN JS LMM.