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Research Article

Abnormal Cognition, Sleep, EEG and Brain Metabolism in a Novel Knock-In Alzheimer Mouse, PLB1

  • Bettina Platt mail,

    b.platt@abdn.ac.uk

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Benjamin Drever,

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • David Koss,

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Sandra Stoppelkamp,

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Amar Jyoti,

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Andrea Plano,

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Aneli Utan,

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Georgina Merrick,

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Duncan Ryan,

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Valeria Melis,

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Hong Wan,

    Affiliation: Translational & Molecular Medicine, Pfizer BioTherapeutics, Collegeville, Pennsylvania, United States of America

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  • Marco Mingarelli,

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Emanuele Porcu,

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Louise Scrocchi,

    Affiliation: Amorfix Life Sciences, Mississauga, Ontario, Canada

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  • Andy Welch,

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Gernot Riedel

    Affiliation: School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

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  • Published: November 11, 2011
  • DOI: 10.1371/journal.pone.0027068

About the Authors

Bettina Platt, Benjamin Drever, David Koss, Sandra Stoppelkamp, Amar Jyoti, Andrea Plano, Aneli Utan, Georgina Merrick, Duncan Ryan, Valeria Melis, Marco Mingarelli, Emanuele Porcu, Andy Welch, Gernot Riedel
School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom
Hong Wan
Translational & Molecular Medicine, Pfizer BioTherapeutics, Collegeville, Pennsylvania, United States of America
Louise Scrocchi
Amorfix Life Sciences, Mississauga, Ontario, Canada

Corresponding Author

Email: b.platt@abdn.ac.uk

Competing Interests

The authors have read the journal's policy and report the following conflicts: a patent has been submitted on the PLB1 knock-in mouse (US 12/833474). HW is an employee of Pfizer BioTherapeutics, LS is an employee of Amofrix Life Sciences. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Analyzed the data: BP GR BD DR AJ VM GM AP AW. Wrote the paper: BP GR. Designed all experiments and conducted the final data analyses: BP GR. Contributed to the study design: HW. In vitro electrophysiology: BD. Tissue analyses, genotyping and histology: DK SS. Behaviour: DR EP GM AU VM. EEG/activity: AJ AP. PET imaging: AW MM. Amyloid assay: LS.