About the Authors

Sara D. Lawhon

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A &M University, College Station, Texas, United States of America

Sangeeta Khare

Current address: National Center for Toxicological Research, United States-Food and Drug Administration, Jefferson, Arizona, United States of America

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A &M University, College Station, Texas, United States of America

Carlos A. Rossetti

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A &M University, College Station, Texas, United States of America

Robin E. Everts

Current address: Sequenom Inc, San Diego, California, United States of America

Affiliation Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

Cristi L. Galindo

Affiliation Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, Dallas, Texas, United States of America

Sarah A. Luciano

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A &M University, College Station, Texas, United States of America

Josely F. Figueiredo

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A &M University, College Station, Texas, United States of America

Jairo E. S. Nunes

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A &M University, College Station, Texas, United States of America

Tamara Gull

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A &M University, College Station, Texas, United States of America

George S. Davidson

Affiliation Sandia National Laboratories, Computation, Computers and Mathematics Center, Albuquerque, New Mexico, United States of America

Kenneth L. Drake

Affiliation Serologix, LLC, Austin, Texas, United States of America

Harold R. Garner

Affiliation Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, Dallas, Texas, United States of America

Harris A. Lewin

Affiliation Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

Andreas J. Bäumler

Affiliation Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California, United States of America

Leslie Garry Adams

gadams@cvm.tamu.edu

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A &M University, College Station, Texas, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: KD is employed by Seralogix, LLC where his primary role is Chief Technology Officer. Seralogix is a bioinformatics research and services company commercializing computational systems biology software tools that are being sponsored by the National Institute of Allergy and Infectious Diseases and the National Human Genome Research Institute. KD participated in conducting certain genomic data processing involving pathway analyses and modeling that helped to provide a more system level perspective of host immune response to the Texas A&M University researchers. Data were processed by KD, utilizing Seralogix's proprietary computational pipeline for biological systems analysis. The relation between Seralogix and Texas A&M University, College of Veterinary Medicine is strictly on a collaborative (mutually beneficial) research basis with no financial arrangements, commitments or interests. KD's motivation is to see his computational tools produce results that contribute to the improved understanding of host response to pathogen invasions (an objective of his National Health Institute research grants). KD contributed to the interpretation of the analysis results provided to the Texas A&M University researchers. Seralogix has no ownership of the data, nor results produced by their tools. RE is currently employed by Sequenom Inc. SK is currently employed by the United States Food and Drug Administration. This does not alter the authors′ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SDL AJB LGA. Performed the experiments: SDL SK CAR JFF JESN TG LGA. Analyzed the data: SDL CLG KD. Contributed reagents/materials/analysis tools: REE CLG HRG HAL. Wrote the paper: SDL. Provided support as a technician: SAL. Critically reviewed data and manuscript: SDL KD SK CAR CLG SAL JFF JESN TG GSD HAL AJB LGA.