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Research Article

Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice

  • Mian Bi,

    Affiliation: Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia

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  • Arne Ittner,

    Affiliations: Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia, Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia

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  • Yazi D. Ke,

    Affiliation: Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia

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  • Jürgen Götz,

    Affiliation: Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia

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  • Lars M. Ittner mail

    lars.ittner@sydney.edu.au

    Affiliation: Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia

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  • Published: December 08, 2011
  • DOI: 10.1371/journal.pone.0026860

About the Authors

Mian Bi, Arne Ittner, Yazi D. Ke, Lars M. Ittner
Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia
Arne Ittner, Jürgen Götz
Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia

Corresponding Author

Email: lars.ittner@sydney.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MB LMI. Performed the experiments: MB AI YDK LMI. Analyzed the data: MB AI YDK LMI. Wrote the paper: JG LMI.