Sleep Loss Reduces the DNA-Binding of BMAL1, CLOCK, and NPAS2 to Specific Clock Genes in the Mouse Cerebral Cortex

Valérie Mongrain; Francesco La Spada; Thomas Curie; Paul Franken

doi:10.1371/journal.pone.0026622

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Open Access

Peer-reviewed

Research Article

Sleep Loss Reduces the DNA-Binding of BMAL1, CLOCK, and NPAS2 to Specific Clock Genes in the Mouse Cerebral Cortex

Valérie Mongrain ,

Contributed equally to this work with: Valérie Mongrain, Francesco La Spada

* E-mail: paul.franken@unil.ch (PF); valerie.mongrain@umontreal.ca(VM)

Affiliations Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland, Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Department of Psychiatry, Université de Montréal, Montréal, Canada
⨯
Francesco La Spada ,

Contributed equally to this work with: Valérie Mongrain, Francesco La Spada

Affiliation Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
⨯
Thomas Curie,

Affiliation Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
⨯
Paul Franken

* E-mail: paul.franken@unil.ch (PF); valerie.mongrain@umontreal.ca(VM)

Affiliation Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
⨯

Sleep Loss Reduces the DNA-Binding of BMAL1, CLOCK, and NPAS2 to Specific Clock Genes in the Mouse Cerebral Cortex

Valérie Mongrain,
Francesco La Spada,
Thomas Curie,
Paul Franken

Published: October 24, 2011
https://doi.org/10.1371/journal.pone.0026622

About the Authors

Valérie Mongrain

Contributed equally to this work with: Valérie Mongrain, Francesco La Spada

* E-mail: paul.franken@unil.ch (PF); valerie.mongrain@umontreal.ca(VM)

Affiliations Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland, Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Department of Psychiatry, Université de Montréal, Montréal, Canada

Francesco La Spada

Contributed equally to this work with: Valérie Mongrain, Francesco La Spada

Affiliation Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

Thomas Curie

Affiliation Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

Paul Franken

* E-mail: paul.franken@unil.ch (PF); valerie.mongrain@umontreal.ca(VM)

Affiliation Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VM PF. Performed the experiments: VM FL TC. Analyzed the data: VM FL. Contributed reagents/materials/analysis tools: PF. Wrote the paper: VM FL PF.

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DNA transcription
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Sleep
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Transcription factors
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Chromatin
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Gene expression
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Cerebral cortex
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Immunoprecipitation
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Gene regulation
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