Accumulation of Wildtype and ALS-Linked Mutated VAPB Impairs Activity of the Proteasome

Anice Moumen; Isabelle Virard; Cédric Raoul

doi:10.1371/journal.pone.0026066

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Open Access

Peer-reviewed

Research Article

Accumulation of Wildtype and ALS-Linked Mutated VAPB Impairs Activity of the Proteasome

Anice Moumen,

Affiliations Inserm-Avenir team, the Mediterranean Institute of Neurobiology, INMED, Marseille, France, Université de la Méditerranée, UMR S901 Aix-Marseille 2, Marseille, France
⨯
Isabelle Virard,

Affiliations Inserm-Avenir team, the Mediterranean Institute of Neurobiology, INMED, Marseille, France, Université de la Méditerranée, UMR S901 Aix-Marseille 2, Marseille, France
⨯
Cédric Raoul

* E-mail: cedric.raoul@inserm.fr

Affiliations Inserm-Avenir team, the Mediterranean Institute of Neurobiology, INMED, Marseille, France, Université de la Méditerranée, UMR S901 Aix-Marseille 2, Marseille, France
⨯

Accumulation of Wildtype and ALS-Linked Mutated VAPB Impairs Activity of the Proteasome

Anice Moumen,
Isabelle Virard,
Cédric Raoul

Published: October 5, 2011
https://doi.org/10.1371/journal.pone.0026066

About the Authors

Anice Moumen

Affiliations Inserm-Avenir team, the Mediterranean Institute of Neurobiology, INMED, Marseille, France, Université de la Méditerranée, UMR S901 Aix-Marseille 2, Marseille, France

Isabelle Virard

Affiliations Inserm-Avenir team, the Mediterranean Institute of Neurobiology, INMED, Marseille, France, Université de la Méditerranée, UMR S901 Aix-Marseille 2, Marseille, France

Cédric Raoul

* E-mail: cedric.raoul@inserm.fr

Affiliations Inserm-Avenir team, the Mediterranean Institute of Neurobiology, INMED, Marseille, France, Université de la Méditerranée, UMR S901 Aix-Marseille 2, Marseille, France

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AM CR. Performed the experiments: AM IV. Analyzed the data: AM CR. Wrote the paper: AM IV CR.

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Proteasomes
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Hyperexpression techniques
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Transfection
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Endoplasmic reticulum
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Endoplasmic reticulum stress response
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Amyotrophic lateral sclerosis
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Cytoplasmic inclusions
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Detergents
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