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Research Article

Structural and Biochemical Studies of Human 4-hydroxy-2-oxoglutarate Aldolase: Implications for Hydroxyproline Metabolism in Primary Hyperoxaluria

  • Travis J. Riedel,

    Affiliation: Center for Structural Biology and Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Lynnette C. Johnson,

    Affiliation: Center for Structural Biology and Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • John Knight,

    Affiliation: Division of Urology, Department of Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Roy R. Hantgan,

    Affiliation: Center for Structural Biology and Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Ross P. Holmes,

    Affiliation: Division of Urology, Department of Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • W. Todd Lowther mail

    tlowther@wakehealth.edu

    Affiliation: Center for Structural Biology and Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Published: October 06, 2011
  • DOI: 10.1371/journal.pone.0026021

About the Authors

Travis J. Riedel, Lynnette C. Johnson, Roy R. Hantgan, W. Todd Lowther
Center for Structural Biology and Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
John Knight, Ross P. Holmes
Division of Urology, Department of Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Corresponding Author

Email: tlowther@wakehealth.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TJR LCJ RPH WTL. Performed the experiments: TJR LCJ JK. Analyzed the data: TJR LCJ JK RRH RPH WTL. Wrote the paper: TJR LCJ RPH WTL.