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Research Article

Human Glial-Restricted Progenitor Transplantation into Cervical Spinal Cord of the SOD1G93A Mouse Model of ALS

  • Angelo C. Lepore,

    Affiliation: Department of Neuroscience, Thomas Jefferson University Medical College, Philadelphia, Pennsylvania, United States of America

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  • John O'Donnell,

    Affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Andrew S. Kim,

    Affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Timothy Williams,

    Affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Alicia Tuteja,

    Affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Mahendra S. Rao,

    Affiliations: Life Technologies, Carlsbad, California, United States of America, Q Therapeutics, Salt Lake City, Utah, United States of America

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  • Linda L. Kelley,

    Affiliation: Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America

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  • James T. Campanelli,

    Affiliations: Q Therapeutics, Salt Lake City, Utah, United States of America, Department of Neurology, University of Utah, Salt Lake City, Utah, United States of America

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  • Nicholas J. Maragakis mail

    nmaragak@jhmi.edu

    Affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Published: October 05, 2011
  • DOI: 10.1371/journal.pone.0025968

About the Authors

Angelo C. Lepore
Department of Neuroscience, Thomas Jefferson University Medical College, Philadelphia, Pennsylvania, United States of America
John O'Donnell, Andrew S. Kim, Timothy Williams, Alicia Tuteja, Nicholas J. Maragakis
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Mahendra S. Rao
Life Technologies, Carlsbad, California, United States of America
Linda L. Kelley
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
Mahendra S. Rao, James T. Campanelli
Q Therapeutics, Salt Lake City, Utah, United States of America
James T. Campanelli
Department of Neurology, University of Utah, Salt Lake City, Utah, United States of America

Corresponding Author

Email: nmaragak@jhmi.edu

Competing Interests

JC and MR have a financial interest and are associated with Q Therapeutics Inc., which provided the hGRPs for transplantation. MR is the Vice President for Research, Regenerative Medicine and Stem Cells at Life Technologies. Q Therapeutics, Inc. has patents on hGRPs and is currently developing these for potential clinical study. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AL NM JC MR. Performed the experiments: AL JD AK TW AT. Analyzed the data: AL JC NM. Contributed reagents/materials/analysis tools: LK. Wrote the paper: AL NM JC.