About the Authors

Rishi R. Rampersad

Affiliation Department of Medicine, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Teresa K. Tarrant

Affiliation Department of Medicine, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Christopher T. Vallanat

Affiliation Department of Medicine, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Tatiana Quintero-Matthews

Affiliation Department of Medicine, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Michael F. Weeks

Affiliation Department of Medicine, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Denise A. Esserman

Affiliations Division of General Medicine and Clinical Epidemiology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Jennifer Clark

Affiliation Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Franco Di Padova

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Dhavalkumar D. Patel

Affiliations Department of Medicine, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Novartis Institutes for BioMedical Research, Basel, Switzerland

Alan M. Fong

Affiliation Department of Medicine, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Peng Liu

liupz@med.unc.edu

Affiliation Department of Medicine, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Competing Interests

Drs. Patel, DD and Di Padova, F are employees of Novartis Institutes for BioMedical Research. All other authors report no potential conflicts. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PL. Performed the experiments: PL RRR CTV TQ MFW. Analyzed the data: PL RRR TKT DAE DDP. Contributed reagents/materials/analysis tools: PL AMF DDP FDP DAE JC. Wrote the paper: PL RRR.