About the Authors
- Sarah S. Murray
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Affiliation Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, California, United States of America
- Erin N. Smith
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Affiliation Department of Pediatrics and Rady's Children's Hospital, University of California at San Diego, School of Medicine, La Jolla, California, United States of America
- Nikki Villarasa
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Affiliation Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, California, United States of America
- Tara Nahey
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Affiliation Ventures and New Therapies, Medtronic, Inc, Fridley, Minnesota, United States of America
- Jeff Lande
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Affiliation Ventures and New Therapies, Medtronic, Inc, Fridley, Minnesota, United States of America
- Harold Goldberg
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Affiliation Ventures and New Therapies, Medtronic, Inc, Fridley, Minnesota, United States of America
- Marian Shaw
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Affiliation Sequenom, Inc., San Diego, California, United States of America
- Lawrence Rosenthal
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Affiliation University of Massachusetts, Worcester, Massachusetts, United States of America
- Brian Ramza
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Affiliation St. Luke's Health System, Mid America Heart Institute, Kansas City, Missouri, United States of America
- Jamshid Alaeddini
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Affiliation Inland Cardiology Associates, Spokane, Washington, United States of America
- Xinqiang Han
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Affiliation Richmond Cardiology Associates, Richmond, Indiana, United States of America
- Samir Damani
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Affiliation Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, California, United States of America
- Orhan Soykan
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Affiliation Ventures and New Therapies, Medtronic, Inc, Fridley, Minnesota, United States of America
- Robert C. Kowal
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* E-mail: etopol@scripps.edu (EJT); robert.kowal@heartplace.com (RCK)
Affiliation Baylor Heart and Vascular Hospital, Baylor University Medical Center, Dallas, Texas, United States of America
- Eric J. Topol
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* E-mail: etopol@scripps.edu (EJT); robert.kowal@heartplace.com (RCK)
Affiliation Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, California, United States of America
- on behalf of the GAME Investigators
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¶Membership of the GAME –
G eneticA rrhythmiaM arkers forE arly Detection is provided in the Appendix.
Competing Interests
Funding for this study was made in part by Medtronic (OS, TN, JL, HG, RCK-consultant), Scripps Health (SSM, EJT, ENS, NV, MS, SD) and NIH/NCRR UL1RR025774 (SSM, SD, EJT). The funders' role in the study pertains to the specific contributions of the authors as listed above, including study design, data collection and analysis, decision to publish and assistance with preparation of the manuscript. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: SSM EJT RCK OS. Performed the experiments: ENS NV TN JL SD MS. Analyzed the data: HG LR BR JA XH EJT SSM OS RCK. Wrote the paper: SSM ENS EJT.