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Research Article

Oral Treatment with γ-Aminobutyric Acid Improves Glucose Tolerance and Insulin Sensitivity by Inhibiting Inflammation in High Fat Diet-Fed Mice

  • Jide Tian mail,

    jtian@mednet.ucla.edu

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Hoa N. Dang,

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Jing Yong,

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Wing-Sheung Chui,

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Matthew P. G. Dizon,

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Catherine K. Y. Yaw,

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Daniel L. Kaufman

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Published: September 22, 2011
  • DOI: 10.1371/journal.pone.0025338

About the Authors

Jide Tian, Hoa N. Dang, Jing Yong, Wing-Sheung Chui, Matthew P. G. Dizon, Catherine K. Y. Yaw, Daniel L. Kaufman
Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

Corresponding Author

Email: jtian@mednet.ucla.edu

Competing Interests

Drs. Jide Tian and Daniel L. Kaufman are co-inventors of a patent titled “GABA Modulates Inflammation”, but both had no patent-related activity of employment, consultancy, products in development or modified products. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The authors declare no other conflicts of interest.

Author Contributions

Conceived and designed the experiments: JT DLK. Performed the experiments: JT JY HND W-SC MPGD CKYY. Analyzed the data: JT HND JY. Wrote the paper: JT DLK.