The Use of Spinning-Disk Confocal Microscopy for the Intravital Analysis of Platelet Dynamics in Response to Systemic and Local Inflammation

Craig N. Jenne; Connie H. Y. Wong; Björn Petri; Paul Kubes

doi:10.1371/journal.pone.0025109

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Open Access

Peer-reviewed

Research Article

The Use of Spinning-Disk Confocal Microscopy for the Intravital Analysis of Platelet Dynamics in Response to Systemic and Local Inflammation

Craig N. Jenne,

Affiliations Calvin, Phoebe & Joan Snyder Institute for Infection, Immunity & Inflammation, University of Calgary, Calgary, Alberta, Canada, Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada
⨯
Connie H. Y. Wong,

Affiliations Calvin, Phoebe & Joan Snyder Institute for Infection, Immunity & Inflammation, University of Calgary, Calgary, Alberta, Canada, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
⨯
Björn Petri,

Affiliations Calvin, Phoebe & Joan Snyder Institute for Infection, Immunity & Inflammation, University of Calgary, Calgary, Alberta, Canada, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
⨯
Paul Kubes

* E-mail: pkubes@ucalgary.ca

Affiliations Calvin, Phoebe & Joan Snyder Institute for Infection, Immunity & Inflammation, University of Calgary, Calgary, Alberta, Canada, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
⨯

The Use of Spinning-Disk Confocal Microscopy for the Intravital Analysis of Platelet Dynamics in Response to Systemic and Local Inflammation

Craig N. Jenne,
Connie H. Y. Wong,
Björn Petri,
Paul Kubes

Published: September 19, 2011
https://doi.org/10.1371/journal.pone.0025109

About the Authors

Craig N. Jenne

Affiliations Calvin, Phoebe & Joan Snyder Institute for Infection, Immunity & Inflammation, University of Calgary, Calgary, Alberta, Canada, Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada

Connie H. Y. Wong

Affiliations Calvin, Phoebe & Joan Snyder Institute for Infection, Immunity & Inflammation, University of Calgary, Calgary, Alberta, Canada, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada

Björn Petri

Paul Kubes

* E-mail: pkubes@ucalgary.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CNJ PK. Performed the experiments: CNJ CHYW BP. Analyzed the data: CNJ. Contributed reagents/materials/analysis tools: PK. Wrote the paper: CNJ.

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Platelets
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Neutrophils
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Platelet aggregation
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Kupffer cells
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Mice
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Endothelium
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Sine waves
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Platelet activation
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