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Research Article

Insights into the Molecular Mechanisms of the Anti-Atherogenic Actions of Flavonoids in Normal and Obese Mice

  • Elena V. Shabrova,

    Affiliations: Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States of America, Food Science Department and Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States of America

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  • Olga Tarnopolsky,

    Affiliation: Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States of America

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  • Ajay P. Singh,

    Affiliation: Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States of America

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  • Jorge Plutzky,

    Affiliation: Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America

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  • Nicholi Vorsa mail,

    quadro@aesop.rutgers.edu (LQ); vorsa@aesop.rutgers.edu (NV)

    Affiliations: Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States of America, PE Marucci Center, Rutgers, The State University of New Jersey, Chatsworth, New Jersey, United States of America

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  • Loredana Quadro mail

    quadro@aesop.rutgers.edu (LQ); vorsa@aesop.rutgers.edu (NV)

    Affiliation: Food Science Department and Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States of America

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  • Published: October 10, 2011
  • DOI: 10.1371/journal.pone.0024634

About the Authors

Elena V. Shabrova, Olga Tarnopolsky, Ajay P. Singh, Nicholi Vorsa
Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States of America
Jorge Plutzky
Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America
Nicholi Vorsa
PE Marucci Center, Rutgers, The State University of New Jersey, Chatsworth, New Jersey, United States of America
Elena V. Shabrova, Loredana Quadro
Food Science Department and Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LQ EVS. Performed the experiments: EVS OT. Analyzed the data: EVS LQ. Contributed reagents/materials/analysis tools: AS NV. Wrote the paper: ES LQ NV. Provided insight into the analysis and interpretation of the results and critical comments on the manuscript: JP.