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Research Article

A Network-Based Approach to Prioritize Results from Genome-Wide Association Studies

  • Nirmala Akula mail,

    akulan@mail.nih.gov

    Affiliation: Mood and Anxiety Section, Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Ancha Baranova,

    Affiliations: School of Systems Biology, College of Science, George Mason University, Fairfax, Virginia, United States of America, Research Center for Medical Genetics, RAMS, Moscow, Russian Federation

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  • Donald Seto,

    Affiliation: School of Systems Biology, College of Science, George Mason University, Fairfax, Virginia, United States of America

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  • Jeffrey Solka,

    Affiliation: School of Systems Biology, College of Science, George Mason University, Fairfax, Virginia, United States of America

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  • Michael A. Nalls,

    Affiliation: Molecular Genetics Section, Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • Andrew Singleton,

    Affiliation: Molecular Genetics Section, Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • Luigi Ferrucci,

    Affiliation: Longitudinal Studies Section, Clinical Research Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Toshiko Tanaka,

    Affiliation: Longitudinal Studies Section, Clinical Research Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Stefania Bandinelli,

    Affiliation: Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy

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  • Yoon Shin Cho,

    Affiliation: Center for Genome Science, National Institute of Health, Seoul, Korea

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  • Young Jin Kim,

    Affiliation: Center for Genome Science, National Institute of Health, Seoul, Korea

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  • Jong-Young Lee,

    Affiliation: Center for Genome Science, National Institute of Health, Seoul, Korea

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  • Bok-Ghee Han,

    Affiliation: Center for Genome Science, National Institute of Health, Seoul, Korea

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  • Bipolar Disorder Genome Study (BiGS) Consortium,

    The member institutions of the Bipolar Disorder Genome Study (BiGS) Consortium are listed in the Acknowledgments.

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  • The Wellcome Trust Case-Control Consortium,
  • Francis J. McMahon

    Affiliation: Mood and Anxiety Section, Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Published: September 06, 2011
  • DOI: 10.1371/journal.pone.0024220

About the Authors

Nirmala Akula, Francis J. McMahon
Mood and Anxiety Section, Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
Ancha Baranova, Donald Seto, Jeffrey Solka
School of Systems Biology, College of Science, George Mason University, Fairfax, Virginia, United States of America
Ancha Baranova
Research Center for Medical Genetics, RAMS, Moscow, Russian Federation
Michael A. Nalls, Andrew Singleton
Molecular Genetics Section, Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
Luigi Ferrucci, Toshiko Tanaka
Longitudinal Studies Section, Clinical Research Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Stefania Bandinelli
Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy
Yoon Shin Cho, Young Jin Kim, Jong-Young Lee, Bok-Ghee Han
Center for Genome Science, National Institute of Health, Seoul, Korea

Corresponding Author

Email: akulan@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NA FJM. Analyzed the data: NA FJM. Contributed reagents/materials/analysis tools: MAN AS LF TT SB YSC YJK JYL BGH BiGS Consortium. Edited the manuscript: AB DS JS FJM. Wrote the manuscript: NA.