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Research Article

Functional Polymorphism of the Mu-Opioid Receptor Gene (OPRM1) Influences Reinforcement Learning in Humans

  • Mary R. Lee mail,

    leemary@mail.nih.gov

    Affiliation: National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, United States of America

    X
  • Courtney L. Gallen,

    Affiliation: National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, United States of America

    X
  • Xiaochu Zhang,

    Affiliation: National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, United States of America

    X
  • Colin A. Hodgkinson,

    Affiliation: National Institute on Alcohol Abuse and Alcoholism, Intramural Research Program, Rockville, Maryland, United States of America

    X
  • David Goldman,

    Affiliation: National Institute on Alcohol Abuse and Alcoholism, Intramural Research Program, Rockville, Maryland, United States of America

    X
  • Elliot A. Stein,

    Affiliation: National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, United States of America

    X
  • Christina S. Barr

    Affiliation: National Institute on Alcohol Abuse and Alcoholism, Intramural Research Program, Rockville, Maryland, United States of America

    X
  • Published: September 02, 2011
  • DOI: 10.1371/journal.pone.0024203

About the Authors

Mary R. Lee, Courtney L. Gallen, Xiaochu Zhang, Elliot A. Stein
National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, United States of America
Colin A. Hodgkinson, David Goldman, Christina S. Barr
National Institute on Alcohol Abuse and Alcoholism, Intramural Research Program, Rockville, Maryland, United States of America

Corresponding Author

Email: leemary@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ML XZ CG ES CB. Performed the experiments: XZ CH. Analyzed the data: ML CG XZ CB. Contributed reagents/materials/analysis tools: CH DG. Wrote the paper: ML CG CB.