About the Authors

Jian feng Zhu

Contributed equally to this work with: Jian feng Zhu, Zi jian Li

Affiliation Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Zi jian Li

Contributed equally to this work with: Jian feng Zhu, Zi jian Li

Affiliation Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Guang sen Zhang

zgsllzy@163.com (GsZ); kunm88@yahoo.com (KM)

Affiliation Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Kun Meng

zgsllzy@163.com (GsZ); kunm88@yahoo.com (KM)

Affiliation Shenogen Biomedical Co, Ltd, Beijing, Haidian, Beijing, People's Republic of China

Wen yong Kuang

Affiliation Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Jin Li

Affiliation Shenogen Biomedical Co, Ltd, Beijing, Haidian, Beijing, People's Republic of China

Xin fu Zhou

Affiliation Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Rui juan Li

Affiliation Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Hong ling Peng

Affiliation Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Chong wen Dai

Affiliation Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Jian Kai Shen

Affiliation Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Fan jie Gong

Affiliation Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Yun xiao Xu

Affiliation Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Su fang Liu

Affiliation Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Competing Interests

Kun Meng and Jin Li are employees of Shenogen Biomedical Co, Ltd. The drug Icaritin was provided by Shenogen Biomedical Co, Ltd., who have the patent for the drug Icaritin (patent number 200710179673.8, date: 2007.12.17). There are no other products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: GsZ. Performed the experiments: JfZ ZjL WyK XfZ RjL HlP FjG SfL. Analyzed the data: JfZ GsZ ZjL KM. Contributed reagents/materials/analysis tools: KM JL CwD JKS YxX. Wrote the paper: GsZ.