About the Authors

Melinda Butsch Kovacic

Affiliations Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Jocelyn M. Biagini Myers

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Ning Wang

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Lisa J. Martin

Affiliation Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Mark Lindsey

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Mark B. Ericksen

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Hua He

Affiliation Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Tia L. Patterson

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Tesfaye M. Baye

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Dara Torgerson

Affiliation The Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, United States of America

Lindsey A. Roth

Affiliation The Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, United States of America

Jayanta Gupta

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Umasundari Sivaprasad

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Aaron M. Gibson

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Anna M. Tsoras

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Donglei Hu

Affiliations The Lung Biology Center, San Francisco General Hospital, San Francisco, California, United States of America, The Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

Celeste Eng

Affiliations The Lung Biology Center, San Francisco General Hospital, San Francisco, California, United States of America, The Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

Rocío Chapela

Affiliation Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

José R. Rodríguez-Santana

Affiliation Centro de Neumología Pediátrica, CSP, San Juan, Puerto Rico, United States of America

William Rodríguez-Cintrón

Affiliation San Juan Veterans Affairs Medical Center, University of Puerto Rico School of Medicine, San Juan, Puerto Rico, United States of America

Pedro C. Avila

Affiliation Division of Allergy-Immunology, Northwestern University, Chicago, Illinois, United States of America

Kenneth Beckman

Affiliation Biomedical Genomics Center, University of Minnesota, Minneapolis, Minnesota, United States of America

Max A. Seibold

Affiliation Department of Medicine, National Jewish Health, Denver, Colorado, United States of America

Chris Gignoux

Affiliation The Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

Salma M. Musaad

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Weiguo Chen

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Esteban González Burchard

Affiliations The Lung Biology Center, San Francisco General Hospital, San Francisco, California, United States of America, The Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America, The Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, United States of America

Gurjit K. Khurana Hershey

gurjit.hershey @cchmc.org

Affiliation Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Competing Interests

Mr. Chris Gignoux has indicated that he holds stock in 23andMe, Inc. The other authors do not have any conflicts of interest or financial disclosures, including declarations of financial interest, to report.

Author Contributions

Conceived and designed the experiments: GKKH NW. Performed the experiments: MBE JG AMT TP WC US AMG. Analyzed the data: NW HH LR CG DH LJM TMB CE MS. Contributed reagents/materials/analysis tools: RC JRR-S WR-C PCA KB EGB. Wrote the paper: MBK JMBM. Provided conceptual advice and critical review of the manuscript: GKKH LJM US TMB DT JG. Directed the statistical analysis: MBK JMBM LJM DT. Planned and oversaw the discovery cohort and African American subject recruitment, data collection and storage: MBK JMBM TP GKKH. Oversaw the data storage and management and prepared the data for analysis: ML JMBM MBK. Oversaw selection of SNPs for placement on the custom SNP array: NW SM GKKH. Recruited subjects: MBE JG AMT TP.